个人简介
主要从事微流控筛选与分子识别研究，从机理机制、方法建立及体系应用等方面取得一系列创新成果：1) 通过对生物分子（多肽等）多级结构的精准设计裁剪，提出了复杂体系中多元分子识别作用有序解析新机理；2) 建立了微流控芯片分子定向进化新方法，拓宽了分子筛选的通量和维度；3) 开发了一系列针对复杂体系高选择性识别的新型多肽探针并用于活体内化学测量。在SCI期刊以通讯和第一作者发表论文40余篇（含唯一通讯10篇），包括Angew Chem Int Ed、Chem Sci、Adv Mater、ACS Nano、Anal Chem、Lab Chip等。作为项目负责人主持国家自然科学基金委面上项目、青年项目，中央军委后保部开放研究项目，北京市自然科学基金面上项目、青年项目等。2015年入选北京市优秀bob真人app下载青年拔尖人才。2019年入选中科院青促会。以第一完成人获中国分析测试协会科学技术（CAIA奖）二等奖。任北京市色谱学会理事，Journal of Analysis and Testing期刊青年编委。授权发明专利10余项，其中1项已进入临床（体内）应用。
研究领域和方向
1. 靶向分子识别与精准化学测量
2. 微流控芯片高内涵筛选分析
3. 基于多肽分子探针的纳米医学检测
4. 生物分子影像与智能可控生物医用材料
教育背景
2006.09-2011.07，中国科学院化学研究所，分析化学，理学博士；
2002.09-2006.06，bob手机在线登陆，应用化学，理学学士。
工作履历
2019.07至今，bob手机在线登陆，预聘副教授/特别研究员
2016.11-2017.12 斯坦福大学，访问学者
2011.08-2019.06，国家纳米科学中心，助理研究员、副研究员
研究成果
1.Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, Weizhi Wang*. Tailored cross-β assemblies establish peptide “Dominos” structures for anchoring undruggable pharmacophores. Angew. Chem. Int. Ed. 2022, 61, e202212527.
2.Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chem. Sci. 2022, 13, 4052.
3.Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘all-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Adv. Mater. 2022, e202207330.
4.Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, Weizhi Wang*. A “cell space station” for spatiotemporal molecular manipulation of immune checkpoint. ACS Nano 2022, 16, 16332.
5.Shang Wu, Limin Zhang, Weizhi Wang*. Screened α helix peptide inhibitor toward SARS-CoV 2 by blocking a Prion-like domain in the receptor binding domain. Anal. Chem. 2022, 94, 11464.
6.Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Anal. Chem. 2021, 93, 8035.
7.Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology related detection. Anal. Chem. 2022, 94, 431.
8.Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Anal. Chem. 2020, 92, 5650.
9.Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Anal. Chem. 2019, 91, 7245.
10.Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, Weizhi Wang*. Controlled recognition and corona formation by cascade micellar nanoprobes: for boosting glioma theranostics. Anal. Chem. 2022, 94, 11118.
11.Yuwei Tian, Limin Zhang, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosens. Bioelectron. 2021, 184, 113235.
12.Mengzhen Li, Minxuan Wang, Lingyun Li, Limin Zhang, Bing Ma*, Weizhi Wang*. A composite peptide-supramolecular microneedle system for melanoma immunotherapy. Nano Res. 2022, e3032.
13.Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang*. Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring. Biomaterials 2019, 188, 96.
14.Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Adv. Mater. 2018, 30, 1800106.
15.Weizhi Wang*, Zhiyuan Hu*. Targeting peptide-based probes for molecular imaging and diagnosis. Adv. Mater. 2019, 31, 1804827.