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Article Navigation> JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY> 2002> 11(4): 375-377
LI Jia-rong, ZHOU Xin-wo, CHEN Peng, GUO Yong-jian. A Facile Synthesis of 9-Amino-1,2,3,4- Tetrahydroacridine from Isatin[J]. JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2002, 11(4): 375-377.
Citation: LI Jia-rong, ZHOU Xin-wo, CHEN Peng, GUO Yong-jian. A Facile Synthesis of 9-Amino-1,2,3,4- Tetrahydroacridine from Isatin[J].JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2002, 11(4): 375-377.
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A Facile Synthesis of 9-Amino-1,2,3,4- Tetrahydroacridine from Isatin

  • School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China

  • Received Date:2002-01-19
    Abstract
  • Tacrine(9-amino-1,2,3,4-tetrahydroacridine) was synthesized using isatin as the raw material through isatin 3-oxime and 2-aminobenzonitrile with a yield of 68.1%. Sodium methoxide was used as the catalyst in the thermal decomposition of isatin 3-oxime, and tetramethylene sulfone was used as the solvent. The structure of tacrine was determined by IR, 1H NMR, MS and elemental analysis.
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