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CHEN Jie, HUANG Li-na, CHEN Jie. Adaptive Simulated Annealing Based Protein Loop Modeling of Neurotoxins[J]. JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2003, 12(4): 337-341.
Citation: CHEN Jie, HUANG Li-na, CHEN Jie. Adaptive Simulated Annealing Based Protein Loop Modeling of Neurotoxins[J].JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2003, 12(4): 337-341.
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Adaptive Simulated Annealing Based Protein Loop Modeling of Neurotoxins

  • Department of Automatic Control, School of Information Science and Technology, Beijing Institute of Technology, Beijing100081, China

Funds:theMinisterialLevelAdvancedResearchFoundation(2001070)andtheTeachingandResearchAwardProgramforOutstandingYoungTeachersinHigherEducationInstitutionsofMOEofChina
  • Received Date:2003-06-17
    Abstract
  • A loop modeling method, adaptive simulated annealing, for ab initio prediction of protein loop structures, as an optimization problem of searching the global minimum of a given energy function, is proposed. An interface-friendly toolbox—LoopModeller in Windows and Linux systems, VC++ and OpenGL environments is developed for analysis and visualization. Simulation results of three short-chain neurotoxins modeled by LoopModeller show that the method proposed is fast and efficient.
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