Welcome to Journal of Beijing Institute of Technology
Advance Search
Volume 13Issue 1
.
Turn off MathJax
Article Contents
Article Navigation> JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY> 2004> 13(1): 76-79
SUN Jing-guo, YAO Guo-wei, OU Yu-xiang. Comparative Process for the Preparation of 9-Oxime Erythromycin A[J]. JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2004, 13(1): 76-79.
Citation: SUN Jing-guo, YAO Guo-wei, OU Yu-xiang. Comparative Process for the Preparation of 9-Oxime Erythromycin A[J].JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2004, 13(1): 76-79.
shu

Comparative Process for the Preparation of 9-Oxime Erythromycin A

  • 1.

    School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China; School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China; College of Chemistry, Hebei Normal University, Shijiazhuang, Hebei050091, China

  • 2.

    School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China

  • 3.

    School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

Funds:SponsoredbytheTechniquesInnovationFoundationofStateEconomic&TradeCommission(01BK009)
  • Received Date:2003-03-20
    Abstract
  • The comparative process for preparing 9-oxime erythromycin A (EMAO) is investigated. EMAO was synthesized and compared by the reaction of erythromycin and hydroxylamine hydrochloride with various bases such as sodium acetate, triethylamine, etc. A new synthetic method is established. The oximation is performed under dynamic buffer system; less degradation impurities are formed. The yield of EMAO reaches more than 95%, HPLC analysis shows that the purity of EMAO is more than 90%, and the E/Z isomeric ratio preponderates over 7∶1.
    • FullText(HTML)
  • loading
    • References (14)
  • [1]
    Clar k R F,M a Z K,Wang S Y,et al.Synthesis and antibacter ial activ ity of novel 6 O substituted ery thro my cinA deriv at ives[J] .Bioor ganic&M edicinal ChemistryLetters,2000(10):815-819.
    [2]
    Sun Jingguo,Liang Jianhua,Deng Zhihua,et al.Prog ress in synthesis of clarithromy cin[J] .Chinese Journal of Organic Chemistry,2002,22(12):951-963.(inChinese)
    [3]
    M orimoto S,Adachi T,M atsunag a T,et al.Erythromy cin A der ivatives and method for preparing same[P] .USP:6342590 B1,2002-01-29.
    [4]
    Chang Soujen.Process for pr epar ing er ythro mycin Aox ime[P] .WO 97/38000,1997-10-16.
    [5]
    T akehiro A,M asaml G,Kazuto K S,et al.Process forprepar ing ery thromy cin A ox ime or a salt thereof[P] .U SP:5274085,1993-12-28.
    [6]
    Robert R W,M aplew oo d N J.Process for the pr epar ation of 9 deox o 9(Z)hydrox y iminoerythromycin A[P] .U SP:5912331,1999-06-15.
    [7]
    Shi Yan,Q ian G uohua,Liang Jianhua,et al.Synthesisof erythromycin 9 oxime[J] .Chinese Journal of syntheticChemistry,2001,9(2):172-174.
    [8]
    Slobodan D,Zrinka T.Ery thromy cin ox ime and its 9amino deriv ative[P] .BP:1100504,1968-01-24.
    [9]
    A dachi T,M orimoto S,M atsunaga T,et al.Productionof ox ime derivative of erythromycin[P] .JP:62081399,1987-04-14.
    [10]
    Watanabe Y W,M or imoto S,Goi M,et al.M ethodfor selective methylatio n of erythromycin A derivatives[P] .USP:4672109,1987-01-09.
    [11]
    M orimoto S,Adachi T,M atsunag a T,et al.Pr oduction of ox ime derivative of erythromycin[P] .JP:62087599,1987-04-22.
    [12]
    Gasc J C,DAmbrieres S G,Lutz A,et al.New etherox ime der ivative of er ythr omycin A A structure relationship study[J] .Journal of A ntibiotics,1990,43(3):313-330.
    [13]
    Sun Jingguo,Y ao Guow ei.Hig h performance liquidchromatographic analysis of ery thromy cin A oxime andrelative substances[J] .Chinese Journal of AnalyticalChemistry,2003,31(9):1089-1092.(in Chinese)
    [14]
    Chang Sou Jen.Process for preparing er ythro mycin Aox ime[P] .U SP:5808017,1998-09-15
    • Relative Articles
  • Supplements (0)
  • Cited By
  • 加载中

Catalog

    通讯作者:陈斌, bchen63@163.com
    • 1.

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (269) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address:5 Zhongguancun South Street, Haidian District, Beijing

    Tel:86-10-68914374

    Email:blgywb@bit.edu.cn

    Copy Right © Journal of Beijing Institute of Technology

    Supported by:Beijing Renhe Information Technology Co. Ltd

    /

      Return
      Return
        Baidu
        map