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Article Navigation> JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY> 2004> 13(2): 206-209
DAI Rong-ji, TONG Bin, WEI Zheng, GU Jun-ling, DENG Yu-lin, LI Ming-yu, FU Ruo-nong. Synthesis of Amino Acid Derived β-Cyclodextrins Used in Chiral Separation by Capillary Electrophoresis[J]. JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2004, 13(2): 206-209.
Citation: DAI Rong-ji, TONG Bin, WEI Zheng, GU Jun-ling, DENG Yu-lin, LI Ming-yu, FU Ruo-nong. Synthesis of Amino Acid Derived β-Cyclodextrins Used in Chiral Separation by Capillary Electrophoresis[J].JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2004, 13(2): 206-209.
shu

Synthesis of Amino Acid Derived β-Cyclodextrins Used in Chiral Separation by Capillary Electrophoresis

  • 1.

    School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China

  • 2.

    School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

  • 3.

    School of Science, Beijing Institute of Technology, Beijing 100081, China

  • 4.

    School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China

Funds:SponsoredbytheNationalNaturalScienceFoundation(20275004);theBasicResearchFoundationofBeijingInstituteofTechnology(BITUBF200306B06)
  • Received Date:2003-05-22
    Abstract
  • Six new kinds of amino acid derived β-cyclodextrins were synthesized to improve their water solubility and chiral separation properties. They are heptakis{2,6-di-O-[3-L-（1-isopropyl carboxyl methyl amino）-2-（hydroxy） propyl]}-β-cyclodextrin （i.e. L-Val-β-CD）, heptakis{2,6-di-O-[3-L-（1-benzyl carboxyl methyl amino）-2-hydroxy propyl]}-β-cyclodextrin （i.e. L-Phe-β-CD）, heptakis{2,6-di-O-[3-（D, L-1-benzyl carboxyl methyl amino）-2-hydroxy propyl]}-β-cyclodextrin （i.e. D,L-Phe-β-CD）, heptakis{2,6-di-O-[3-（L-1-hydroxymethyl carboxyl methyl amino）-2-hydroxy propyl]}-β-cyclodextrin （i.e. L-Ser-β-CD）, heptakis{2,6-di-O-[3-（L-1-carboxylmethyl carboxyl methyl amino）- 2-hydroxy propyl]}-β-cyclodextrin （i.e. L-Asp-β-CD）, heptakis{2,6-di-O-[3-（L-2-carboxyl tetramethylene amino）-2-hydroxy propyl]}-β-cyclodextrin （i.e. L-Pro-β-CD）. Their chemical structures were certified using FTIR and （） 1H NMR. Except for L-Phe-β-CD and D,L-Phe-β-CD, that are in soluble in water, the other amino acid derived β-CDs all have good water solubility. D,L-tyrosine and promethazine were baselinely separated by L-Val-β-CD in capillary electrophoresis.
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    • References (10)
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