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Article Navigation> JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY> 2010> 19(1): 103-108
LI Yan, XIN Nian. Protective Effects of Qingshen Compound on Experimental Masugi Nephritis Model in Rats[J]. JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2010, 19(1): 103-108.
Citation: LI Yan, XIN Nian. Protective Effects of Qingshen Compound on Experimental Masugi Nephritis Model in Rats[J].JOURNAL OF BEIJING INSTITUTE OF TECHNOLOGY, 2010, 19(1): 103-108.
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Protective Effects of Qingshen Compound on Experimental Masugi Nephritis Model in Rats

  • School of Life Science, Beijing Institute of Technology, Beijing 100081, China

  • Received Date:2009-04-27
    Abstract
  • To study protective effects of Qingshen Compound on experimental anti-glomerular basement membrane antibody (AGBM-Ab) nephritis model in rats, an experimental Masugi nephritis model was established in Sprague-Dawley(SD) rats by a single-dose injection of prepared rabbit anti-rat glomerular basement membrane(GBM) serum into sublingual vein and then effects of Qingshen Compound on urine volume, urinary protein level, blood urea nitrogen (BUN), creatinine (Cr), albumin (Alb), triglycerides (TG), cholesterol (CHO) and histopathological changes were investigated. After successive daily three-dosage oral administration to rat groups (9.4, 4.7, 2.3g ·kg -1) for 8 weeks, Qingshen Compound was proved effective on increasing urine volume and Alb content, and decreasing levels of urinary protein, BUN, Cr and TG. Furthermore, high and middle dosages (9.4, 4.7g ·kg -1) could improve histopathological healing of the model. In summary, Qingshen Compound has shown protective effects on experimental Masugi nephritis model in rats.
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    • References (23)
  • [1]
    Fujimoto T, Okada M, Kondo Y, et al. The nature of masugi nephritis histopathological and immunopathological studies[J]. Acta Pathol Jpn, 1964, 14: 275-310.
    [2]
    Hammer D K, Dixon F J. Immunologic events in the pathogenesis of nephrotoxic serum nephritis in the rat[J]. J Exp Med, 1963, 117: 1019-1042.
    [3]
    Park S Y, Ueda H, Ohno Y, et al. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis[J]. J Clin Invest, 1998, 102: 1229-1238.
    [4]
    Unanue E R, Dixon F J. Experimental glomerulonephritis: immunological events and pathogenetic mechanisms[J]. Adv Immunol, 1967, 6: 1-90.
    [5]
    Pu Xuehua, Xing Changying, Zhu Xuan, et al. Effect of leflunomide on rat with Masugi nephritis[J]. Jiangsu Medical Journal, 2008, 34(5): 497-499. (in Chinese)
    [6]
    Tang Renxian, Jian Jie, Wang Yingwei, et al. The duplication of and observation on anti-glomerular basement membrane (GBM) nephritis in rats[J]. Acta Academiae Medicinae Xuzhou, 2003, 23(1): 913. (in Chinese)
    [7]
    Gunther Z, Gunter W, Saskia S, et al. Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species[J]. Febs Lett, 2006, 580: 2523-2528.
    [8]
    Narsipur S S, Peterson O W, Smith R, et al. Mechanisms of glomerular immune injury: effects of antioxidant treatment[J]. J Am Soc Nephrol, 2003, 14: 1748-1755.
    [9]
    Rogovyi Y E, Arkhipova L G., Dikal M V, et al. Role of CD64, P53 and P21 proteins in the pathogenesis of the tubulo-interstitial syndrome in Masugi chronic nephritis [J]. Bulletin of Experimental Biology and Medicine, 2007, 144(4): 511-514.
    [10]
    Krakower C A, Greenspon S A. Localization of the nephrotoxic antigen within the isolated renal glomerulus[J]. AMA Arch Pathol, 1951, 51: 629-639.
    [11]
    Wada T, Yokoyama H, Furuichi K, et al. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1)[J]. Faseb J, 1996, 10: 1418-1425.
    [12]
    Wang Qiu, Chai Ruihua, Liu Shouyi. Study on therapeutic action of shenfukang to masugi glomerular nephritis of rats[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2008, 10(5): 173-174. (in Chinese)
    [13]
    Clarke B K, Ham K N, Tange J D, et al. Macrophages and glomerular crescnt formation studies with rat nephrotoxic nephritis[J]. Pathclogy, 1983, 15: 75-81.
    [14]
    Hattori T, Nagamatsu T, Ito M, et al. Contribution of ID-1- and CD-8-positive cells to the development of crescentic-type anti-GBM nephritis in rats[J]. Nippon Jinzo Gakkaishi, 1994, 36: 1228-1239.
    [15]
    Boyce N W, Holdsworth S R. Anti-glomerular basement membrane antibody-induced experimental glomerulonephritis: evidence for dose-dependent, direct antibody and complement-induced, cell-independent injury[J]. J Immunol, 1985, 135: 918-3921.
    [16]
    Zhou C, Lv J, Lu R, et al. A new pentapeptide compound, PLNPK, ameliorates anti-glomerular basement membrane nephritis in Wistar rats[J]. Peptides, 2008, 29: 1789-1797.
    [17]
    Hermann Pavebstadt, Wilhelm Kriz, Matthias Kretzler. Cell biology of the glomerular podocyte[J]. Physiol Rev, 2003, 83(1): 253-307.
    [18]
    Fu Hong, Li Qixiong. Protective effects and mechanisms of tetramethypyrazine on accelerated anti-GBM antibody nephritis in rats[J]. Chinese Pharmacological Bulletin, 2004, 20(2): 196-199. (in Chinese)
    [19]
    Vassalli P. The pathogenic role of the coagulation process in rabbit Masugi nephritis[J]. Am J path, 1964, 45: 653.
    [20]
    Fu H, Li J, Li Q, et al. Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties[J]. European Journal of Pharmacology, 2007, 563: 197-202.
    [21]
    Wang H, Chen L, Zhang Z, et al. Ex vivo transfer of the decorin gene into rat glomerulus via a mesangial cell vector suppressed extracellular matrix accumulation in experimental glomerulonephritis[J]. Exp Mol Pathol, 2005, 78: 17-24.
    [22]
    Koryakova N N, Rozhdestvenskaya E D, Kazantseva S V, et al. Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure[J]. Ter Arh, 2006, 78: 14-17.
    [23]
    Pierina D M, Rossana F, Pietro F, et al. Urinary transforming growth factor-beta1 in various types of nephropathy[J]. Pharmacol Res, 2004, 49: 293-298. (Edited by
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